Osmate was a comune (municipality) in the Province of Varese in the Italian region Lombardy, located about 50 kilometres (31 mi) northwest of Milan and about 13 kilometres (8 mi) southwest of Varese. As of 31 December 2004, it had a population of 550 and an area of 3.4 square kilometres (1.3 sq mi).

In 2019 it merged with the nearby Cadrezzate forming the new municipality of Cadrezzate con Osmate.