On 3 June 2022, a double decker regional train derailed north of Garmisch-Partenkirchen, near Burgrain on the Munich–Garmisch-Partenkirchen railway in southern Germany. Five people died and 68 passengers were injured, 16 of them seriously.

Five passenger carriages derailed at a curve near Loisachauen in the Burgrain district of Garmisch-Partenkirchen, heading north between Garmisch-Partenkirchen station and Farchant station. The electric locomotive was at the rear of the push–pull train configuration. The middle three carriages slid down an embankment next to the highway junction of Bundesstraße 23 and Bundesstraße 2 on the approach to the Farchant Tunnel. The derailment occurred at milestone position 97.5 kilometres (60.6 mi), as measured from Munich.