Saint-Jean-de-Maurienne (French pronunciation: [sɛ̃ ʒɑ̃ də mɔʁjɛn] ; Arpitan: Sent-Jian-de-Môrièna or Sant-Jian-de-Môrièna; Italian: San Giovanni di Moriana) is a subprefecture of the Savoie department, in the region of Auvergne-Rhône-Alpes (formerly Rhône-Alpes), in southeastern France.

It lies in the Maurienne, the valley of the river Arc. It was also an Episcopal See of Savoy during the Ancien Régime and again from 1825 to 1966. Its original name was simply Maurienne, or Moriana in Italian and Latin.

Saint-Jean-de-Maurienne is located at the confluence of the Arc, a river which has shaped the Maurienne Valley, and the Arvan which descends the Arves Valley (Col de la Croix de Fer).

The neighbouring communes of Saint-Jean-de-Maurienne are Saint-Julien-Mont-Denis, Jarrier, Hermillon, Villargondran, Albiez-le-Jeune , Albiez-Montrond , Saint-Pancrace and Pontamafrey-Montpascal.