Mendrisio (Italian: [menˈdriːzjo]; Lombard: Mendrís [menˈdriːs]) is a municipality in the district of Mendrisio in the canton of Ticino in Switzerland.

Mendrisio is the seat of the Accademia di Architettura of the university of Italian-speaking Switzerland (USI).

The municipality was boosted in size on 4 April 2004 when it incorporated the former municipality of Salorino. On 5 April 2009 it incorporated the former municipalities of Arzo , Capolago , Genestrerio , Rancate and Tremona. On 14 April 2013 the former municipalities of Besazio , Ligornetto and Meride merged into the municipality of Mendrisio.

Mendrisio is served by Mendrisio railway station and Mendrisio San Martino railway station.