Domodossola railway station (Italian: Stazione di Domodossola) serves the city and comune of Domodossola, in the Piedmont region of northwestern Italy. Opened in 1888, it forms a major break of gauge junction between standard gauge lines to Milan, Brig and Novara, and a metre gauge line to Locarno.

The station is managed by Rete Ferroviaria Italiana (RFI), the commercial area of the passenger building by Centostazioni, while train services on the line to Novara are operated by Trenitalia. Each of these companies is a subsidiary of Ferrovie dello Stato Italiane (FS), Italy's state-owned rail company. The link with Milan is operated by both Trenitalia and Trenord.

Train services on the line to Brig are operated by BLS AG and Swiss Federal Railways, and those on the line to Locarno by the Società Subalpina Imprese Ferroviarie (SSIF).