Domodossola (Italian: [ˌdɔmoˈdɔssola]; Lombard: Dòmm) is a city and comune (municipality) in the Province of Verbano-Cusio-Ossola, in the region of Piedmont, northern Italy. It was also known as Oscela, Oscella, Oscella dei Leponzi, Ossolo, Ossola Lepontiorum, and Domo d'Ossola (due to its position in the Ossola valley), or simply Domo. The Peruvian aviation pioneer, Jorge Chávez, died here in 1910 in an airplane crash.

Domodossola is situated at the confluence of the Bogna and Toce Rivers and is home to 18,300 people.

The city is located at the foot of the Italian Alps and acts as a minor passenger-rail hub. Its strategic location accommodates Swiss rail passengers, and Domodossola railway station acts as an international stopping-point between Milan and Brig (a Swiss city of German language) through the Simplon Pass (Italian: Sempione).