Entlebuch is a municipality in the Canton of Lucerne in Switzerland . It is the seat of the district of Entlebuch. The area has been designated a Biosphere Reserve by UNESCO in 2001.

Entlebuch is first mentioned in 1157, as Entilibuoch, Entelinbuoch. It was in possession of St. Blasien monastery at the time, later passing to the local lords of Wolhusen , who sold it to the House of Habsburg before 1300.