Isenthal is a municipality in the Canton of Uri in Switzerland .

Isenthal is first mentioned in 1280 as Yseltal.

Isenthal has an area, (as of the 2004/09 survey) of 60.97 km2 (23.54 sq mi). Of this area, about 28.0% is used for agricultural purposes, while 27.1% is forested. Of the rest of the land, 0.8% is settled (buildings or roads) and 44.0% is unproductive land. Over the past two decades (1979/85-2004/09) the amount of land that is settled has increased by 17 ha (42 acres) and the agricultural land has decreased by 32 ha (79 acres).