Luzein is a Swiss village in the Prättigau and a municipality in the political district Prättigau/Davos Region in the canton of the Grisons .

Luzein is first mentioned in 1185 as Luzene.

Luzein has an area, as of 2006, of 31.6 km2 (12.2 sq mi). Of this area, 41.8% is used for agricultural purposes, while 46.6% is forested. Of the rest of the land, 3% is settled (buildings or roads) and the remainder (8.6%) is non-productive (rivers, glaciers or mountains).

Before 2017, the municipality was located in the Luzein sub-district of the Prättigau/Davos district (until 2000 part of the former Oberlandquart district).