The Pennine Alps (French: Alpes Pennines, German: Walliser Alpen, Italian: Alpi Pennine, Latin: Alpes Poeninae), sometimes referred to as the Valais Alps (which are just the Northern Swiss part of the Pennine Alps), are a mountain range in the western part of the Alps. They are located in Italy (the Aosta Valley and Piedmont) and Switzerland (Valais).

The Pennine Alps are amongst the three highest major subranges of the Alps, together with the Bernese Alps and the Graian Alps that include the Mont Blanc massif.

The Italian side is drained by the rivers Dora Baltea , Sesia and Toce, tributaries of the Po. The Swiss side is drained by the Rhône.

The Great St Bernard Tunnel, under the Great St Bernard Pass, leads from Martigny, Switzerland to Aosta.