Mezzomerico is a comune (municipality) in the Province of Novara in the Italian region Piedmont , located about 90 kilometres (56 mi) northeast of Turin and about 20 kilometres (12 mi) north of Novara.

Mezzomerico borders the following municipalities: Agrate Conturbia , Divignano , Marano Ticino , Oleggio , Suno, and Vaprio d'Agogna.

The name of the town shows its origins as Celtic Mediomatrici settlement; the name was attested as Mediomadrigo in 980.