The canton of Lucerne (German: Kanton Luzern [ˈkantɔn luˈtsɛrn]; Romansh: Chantun Lucerna; French: Canton de Lucerne; Italian: Cantone Lucerna) is a canton of Switzerland. It is located in the country's central, German-speaking part. The population of the canton (as of 31 December 2020) is 416,347. As of 2007, the population included 57,268 foreigners, or about 15.8% of the total population. The cantonal capital is the city of Lucerne.

The canton of Lucerne comprises territories acquired by its capital Lucerne, either by treaty, armed occupation or purchase.