Piz Zupò (3,995 m) is a mountain in the Bernina Range of the Alps , located on the border between Switzerland and Italy. It lies between the valleys of Morteratsch (Graubünden) and Malenco (Lombardy ). Piz Zupò is the second highest peak in the range after Piz Bernina .

The first ascent of the mountain was made by L. Enderlin and Serardi, with Badrutt (a chamois hunter) on 9 July 1863.