Sizzano is a comune (municipality) in the Province of Novara in the Italian region Piedmont , located about 80 kilometres (50 mi) northeast of Turin and about 20 kilometres (12 mi) northwest of Novara. As of 31 December 2004, it had a population of 1,452 and an area of 10.5 square kilometres (4.1 sq mi).

Sizzano borders the following municipalities: Carpignano Sesia , Cavaglio d'Agogna , Fara Novarese , and Ghemme .

The comune of Sizzano is home to the Denominazione di origine controllata (DOC) wine which includes 20 hectares (50 acres) producing a single red wine. The wine is a blend of 40 to 60% Nebbiolo (known locally as Spanna), 15 to 40% Vespolina and up to 25% of Uva Rara (known locally as Bonarda Novarese). All grapes destined for DOC wine production need to be harvested to a yield no greater than 10 tonnes/ha.