Tirano (Lombard: Tiran; German: Thiran) is a town and comune (municipality) in Valtellina, located in the Province of Sondrio , Lombardy (northern Italy). It has 9,053 inhabitants (2016) and is adjacent to the Italy–Switzerland border . The river Adda flows through the town.

Located nearby is the Catholic shrine of the Madonna di Tirano, a major tourist attraction. The shrine is dedicated to the appearance of the Blessed Mother to Mario Degli Omodei on September 29, 1504, an event religious pilgrims credit with ending a pestilence.

The Museo Etnografico Tiranese (MET) is an ethnographic museum and located nearby the Basilica Madonna di Tirano in an 18th-century Palazzo, the Casa del Penitenziere (Penitent's House).