Zillis-Reischen (Romansh: Ziràn-Reschen) is a municipality in the Viamala Region in the Swiss canton of the Grisons .

Zillis-Reischen was created in 1875 with the union of the previously independent municipalities of Reischen and Zillis. Zillis was first mentioned in the first half of the 9th Century as Ciranes. Reischen was first mentioned in 1219 as de Rexeno.

The municipality site was certainly inhabited even earlier, as a Roman settlement and graves from the 6th or 7th century indicate. A treasure trove of 10th Century coins that were found near the village indicate that there was trade over the Viamala pass by this time.