Airolo (Airöö in Lombard, in Romansh: ) is a municipality in the district of Leventina in the canton of Ticino in Switzerland .

Airolo is located in Leventina valley and the Lepontine Alps , on the southern flank of the St. Gotthard Pass. Both the Gotthard rail tunnel, on the important Gotthard railway linking northern and southern Europe, and the Gotthard road tunnel, on the A2 motorway, have their southern portal in Airolo. It is the largest municipality in the canton of Ticino, and consists of the village of Airolo and the hamlets of Valle, Madrano, Brugnasco, Nante and Fontana. The municipalities of Airolo and Quinto are considering a merger some time in the future into a new municipality which will be known as Airolo-Quinto.