Valsesia (Piedmontese: Valsesia; Walser German: Tseschrutol) is a group of valleys in the north-east of Piedmont in the Province of Vercelli , Italy; the principal valley is that of the river Sesia.

The major towns located here are Varallo Sesia ,Borgosesia , Quarona and Valduggia ; tourist villages include Alagna Valsesia , Rima San Giuseppe , Carcoforo and Scopello . While the valley mainly belongs to the province of Vercelli three of its comuni, namely Romagnano Sesia , Prato Sesia and Grignasco , are part of the Province of Novara ; however, they are not historically part of Valsesia but only geographically.

There are some industries in the lower towns of Varallo, Borgosesia, Quarona and Valduggia. These are mainly the textile industry and precision engineering companies. Agriculture is also practised on the hills along the river Sesia, the wine from Gattinara, which also bears this name, is well known.