Prato Sesia is a comune (municipality) in the Province of Novara in the Italian region Piedmont, located about 80 kilometres (50 mi) northeast of Turin and about 30 kilometres (19 mi) northwest of Novara.

Prato Sesia borders the following municipalities: Boca, Cavallirio, Grignasco, Romagnano Sesia, and Serravalle Sesia.