The Simplon Tunnel (Simplontunnel, Traforo del Sempione or Galleria del Sempione) is a railway tunnel on the Simplon railway that connects Brig, Switzerland and Domodossola , Italy, through the Alps , providing a shortcut under the Simplon Pass route. It is straight except for short curves at either end. It consists of two single-track tunnels built nearly 15 years apart. The first to be opened is 19,803 m (64,970 ft) long; the second is 19,824 m (65,039 ft) long, making it the longest railway tunnel in the world for most of the twentieth century, from 1906 until 1982, when the Daishimizu Tunnel opened.

Culminating at a height of only 705 m (2,313 ft) above sea level, the Simplon Tunnel was also the lowest direct Alpine crossing for 110 years, until the opening of the Gotthard Base Tunnel in 2016. The tunnel has a maximum rock overlay of approximately 2,150 m (7,050 ft), also a world record at the time.