Malesco (Lombard: Malesch) is a comune (municipality) in the Province of Verbano-Cusio-Ossola in the Italian region Piedmont , located about 130 kilometres (81 mi) northeast of Turin and about 20 kilometres (12 mi) north of Verbania , the provincial capital. As of 31 December 2004, it had a population of 1,478 and an area of 43.2 square kilometres (16.7 sq mi).

Malesco is the most populous comune in Val Vigezzo and has a station on the Domodossola –Locarno railway which runs along the valley. The neighbouring municipalities are: Cossogno , Craveggia, Re, Santa Maria Maggiore, Trontano , Valle Cannobina , Villette.