Mesocco (Lombard: Mesòch) is a municipality in the Moesa Region in the Swiss canton of the Grisons .

The first human settlement in the area dates back to the Mesolithic era. Stone tools dating to about 6000 BC have been found in the Silex section of the municipality. At the same site, Neolithic fire pits and ceramics (5000 BC) were also discovered. The first permanent settlements in the area date to the Bronze Age (about 1400-1200 BC) and the pre-Roman Iron Age. A notable necropolis from the early Iron Age (600-500 BC) and traces of a Roman settlement were discovered on Gorda hill near the village.