The Moesa Region is one of the eleven administrative districts in the Canton of the Grisons (or in German: Graubünden) in Switzerland. It had an area of 473.74 square kilometers (182.91 sq mi) and a population of 8,770 (as of 31 December 2020).. It was created on 1 January 2017 as part of a reorganization of the Canton.

The region borders with the Viamala Region to the north, with Italy to the east (Lombardy: Province of Sondrio and of Como) and with the Canton of Ticino (districts of Bellinzona to the southwest, Riviera and Blenio) to the west.

The Moesa region is divided into 12 municipalities:

The Moesa region has about 8500 inhabitants, mostly Italian-speaking, and is part of Italian-speaking Graubünden and Italian-speaking Switzerland. It is linked economically to the Canton of Ticino; linguistically, however, a Lombard Alpine dialect is spoken that is heavily influenced by Germanic terms.