The Moesa Region is one of the eleven administrative districts in the Canton of the Grisons (or in German: Graubünden) in Switzerland . It had an area of 473.74 square kilometers (182.91 sq mi) and a population of 8,770 (as of 31 December 2020).. It was created on 1 January 2017 as part of a reorganization of the Canton.

The region borders with the Viamala Region to the north, with Italy to the east (Lombardy : Province of Sondrio and of Como) and with the Canton of Ticino (districts of Bellinzona to the southwest, Riviera and Blenio ) to the west.

The Moesa region is divided into 12 municipalities:

The Moesa region has about 8500 inhabitants, mostly Italian-speaking, and is part of Italian-speaking Graubünden and Italian-speaking Switzerland. It is linked economically to the Canton of Ticino; linguistically, however, a Lombard Alpine dialect is spoken that is heavily influenced by Germanic terms.