The Onsernone Valley (Italian: Valle Onsernone, German: Onsernonetal), is one of the principal valleys of the Locarno District, in the Swiss Canton of Ticino . The Onsernone Valley derives its name from the Onsernone River, the name used in Italy for what the Swiss call the Isorno , of which it is a river valley. As of 10 April 2016, the municipality of Onsernone is larger than the Valley of Onsernone because Vergeletto and Gresso in the neighboring Valley of Vergeletto were merged into it.

The permanent population of the Onsernone Valley peaked in the 19th century along with local rye straw processing. Relatively undeveloped compared to the rest of Switzerland and with only one road in or out, the Onsernone Valley is often described as "wild," "untamed," and "mysterious" in tourist descriptions. In 2018, the residents of the area voted down a proposal to create a national park in Onsernone out of concern it would usher in a slough of government regulations and bring mass tourism that would end the laid-back lifestyle for which the area is known.