Haute-Saône (French: [ot soːn] ; Frainc-Comtou: Hâte-Saône; English: Upper Saône) is a department in the Bourgogne-Franche-Comté region of northeastern France. Named after the river Saône, it had a population of 235,313 in 2019. Its prefecture is Vesoul; its sole subprefecture is Lure.

The department was created in the early years of the French Revolution through the application of a law dated 22 December 1789, from part of the former province of Franche-Comté. The frontiers of the new department corresponded approximately to those of the old Bailiwick of Amont.

The department was also marked by the Franco-Prussian War with the battles of Héricourt, and Villersexel but also the proximity of the Siege of Belfort.