Palagnedra is a village and a locality part of the municipality of Centovalli in the district of Locarno in the canton of Ticino in Switzerland . Lago di Palagnedra is located below the village, on the Melezza river.

Palagnedra is first mentioned in 1379 as Pallagnidrio.

During the Middle Ages, Palagnedra was the administrative and religious center in the 13th-century Centovalli valley community. In the 16th century it became part of the Locarno and Ascona region, followed by the bailiwick of Locarno. In 1864 the village became independent.