The Drance (French: La Drance/Dranse, French pronunciation: [dʁɑ̃s]) is a river in Valais, Switzerland with a length of 14.5 kilometers (9.0 mi) to the confluence with the Rhône , a maximum length of 43 kilometers (27 mi). It has a drainage basin of 676 square kilometers (261 sq mi). The river is formed from the confluence of the Dranse d'Entremont and the Dranse de Bagnes at the village of Sembrancher . Further upriver the Dranse d'Entremont splits into the Dranse d'Entremont and the Dranse de Ferret.

In 57/56 BC Julius Caesar sent Servius Galba with the Twelfth Legion and some cavalry to open the Great St Bernard Pass . The legion fought the Veragri at the village of Octodurus along the Drance river and drove them across the river before establishing a camp near the river.