The Ossola (Italian: [ˈɔssola]; Ossolano: Òssola), also Valle Ossola or Val d'Ossola (Walser: Eschetaal; German: Eschental), is an area of Northwest Italy situated to the north of Lago Maggiore. It lies within the Province of Verbano-Cusio-Ossola . Its principal river is the Toce , and its most important town Domodossola .

There are many etymological claims as to the origins of the name Ossola, the most likely being Celtic for "high lands". The German and Walser names for the valley translate to "valley of the ash trees".

Ossola is composed of one main valley (the Ossola proper) and seven side valleys: Anzasca, Antrona, Bognanco, Divedro, Antigorio, Formazza, Isorno and Vigezzo.