The Vispa is a river in the canton of Valais, Switzerland, located in the Visp area. It is essentially composed of two large branches: the Matter Vispa and the Saaser Vispa, converging at Stalden, then forming the Vispa proper, flowing for less than 10 kilometres (6.2 mi) before converging with the Rhône at Visp. The Vispa is a left and major affluent of the Rhône, before it enters Lake Geneva.

The Vispa collects the waters from the Mattertal (formed by the Matter Vispa) and the Saastal (formed by the Saaser Vispa), the two highest valleys in Switzerland and the Pennine Alps. Both valleys have mountains over 4,500 metres (14,800 ft) above sea level, the highest being Monte Rosa, the Dom and the Weisshorn, and include numerous glaciers, large and small. As a result, the river is characterized by a glacial regime, similarly to the Massa, another nearby affluent of the Rhône.