The Lütschine (German pronunciation: [ˈlʏtʃinə]) is a river in the Bernese Oberland region of Switzerland. The Lütschine proper runs from Zweilütschinen, where its two tribututaries join, to Lake Brienz at Bönigen. The Schwarze Lütschine, or Black Lütschine, flows from Grindelwald to Zweilütschinen. The Weisse Lütschine, or White Lütschine, flows from the Lauterbrunnen Valley to Zweilütschinen. The common stretch of the river has a length of 8.6 kilometres (5.3 mi), whilst the Schwarze Lütschine is 12.3 kilometres (7.6 mi) long and the Weisse Lütschine is 13.1 kilometres (8.1 mi) long.

Both branches of the Lütschine include a large number of mountain streams as tributaries.