The Grosse Scheidegg (Swiss Standard German pronunciation: [ˈɡroːsə ˈʃaɪdɛg]) is a mountain pass in the Bernese Alps of Switzerland, The pass crosses the col between the Schwarzhorn and the Wetterhorn mountains at an elevation of 1,962 m (6,437 ft).

The pass is traversed by a road connecting the town of Meiringen, at an elevation of 595 m (1,952 ft), with the village of Grindelwald, at an elevation of 1,034 m (3,392 ft). The road is closed to most traffic, but is used by a PostBus Switzerland service from Grindelwald to the summit of the pass, with some buses continuing to Meiringen. Bus services operate between May and October, with between four and ten buses a day depending on time of year and section of the route. Hiking over the pass is popular, and it forms part of the cross-country Alpine Pass Route between Sargans and Montreux.

From the Meiringen side, the approach to the pass runs through the valley of the Reichenbach stream above the Reichenbach Falls, best known as the place of the last fight between Holmes and Moriarty.