Vignone is a comune (municipality) in the Province of Verbano-Cusio-Ossola in the Italian region Piedmont, located about 120 kilometres (75 mi) northeast of Turin and about 2 kilometres (1.2 mi) northeast of Verbania. As of 31 December 2004, it had a population of 1,150 and an area of 3.5 square kilometres (1.4 sq mi).

Vignone borders the following municipalities: Arizzano, Bee, Cambiasca, Caprezzo, Intragna, Premeno, Verbania.