Cannobio is a town and comune on the river Cannobino and the shore of Lago Maggiore in Piedmont, Italy.

The local inhabitants probably became subject to Roman rule by the time of the emperor Augustus. Sarcophagi from the 2nd–3rd century CE have been found and conserved in the "Palazzo della Ragione".

The first documented mention of Cannobio dates to 909. During medieval times, the town became a center for wool and tanning industries, as well as the lumber trade. Cannobio was named as a village by 1207, and was granted administrative autonomy.