Castione Andevenno is a comune (municipality) in the Province of Sondrio in the Italian region Lombardy, located about 90 kilometres (56 mi) northeast of Milan and about 5 kilometres (3 mi) west of Sondrio. As of 31 December 2004, it had a population of 1,545 and an area of 17.1 square kilometres (6.6 sq mi).

Castione Andevenno borders the following municipalities: Albosaggia, Caiolo, Postalesio, Sondrio, Torre di Santa Maria.

The 18th-century church of San Martino is found in the territory.