Esine (Camunian: Éden) is a comune in the province of Brescia, in the Italian region Lombardy, in the Camonica valley, located 43 kilometres (27 miles) north of Brescia.

It is bounded by other communes of Berzo Inferiore, Bovegno, Cividate Camuno, Darfo Boario Terme, Gianico, Piancogno.