The province of Brescia (Italian: provincia di Brescia; Brescian: pruìnsa de Brèsa) is a province in the Lombardy region of Italy. It has a population of 1,266,138. Its capital is the eponymous city of Brescia.

With an area of 4,785.62 km2, it is the largest province of Lombardy. It is also the second province of the region for the number of inhabitants and fifth in Italy (first, excluding metropolitan cities).

It borders the province of Sondrio to the north and north west, the province of Bergamo to the west, the province of Cremona to the south west and south, the province of Mantua to the south.