The Drance (French: La Drance/Dranse, French pronunciation: [dʁɑ̃s]) is a river in Valais, Switzerland with a length of 14.5 kilometers (9.0 mi) to the confluence with the Rhône, a maximum length of 43 kilometers (27 mi). It has a drainage basin of 676 square kilometers (261 sq mi). The river is formed from the confluence of the Dranse d'Entremont and the Dranse de Bagnes at the village of Sembrancher. Further upriver the Dranse d'Entremont splits into the Dranse d'Entremont and the Dranse de Ferret.

In 57/56 BC Julius Caesar sent Servius Galba with the Twelfth Legion and some cavalry to open the Great St Bernard Pass. The legion fought the Veragri at the village of Octodurus along the Drance river and drove them across the river before establishing a camp near the river.