Gignese is a comune (municipality) in the Province of Verbano-Cusio-Ossola in the Italian region Piedmont, located about 110 kilometres (68 mi) northeast of Turin and about 8 kilometres (5 mi) south of Verbania. As of 31 December 2022, it had a population of 1065 and an area of 14.9 square kilometres (5.8 sq mi).

The municipality of Gignese contains the frazioni (subdivisions, mainly villages and hamlets) Alpino, Nocco, and Vezzo.

Gignese borders the following municipalities: Armeno, Brovello-Carpugnino, Omegna, Stresa.