The Alpine Rhine (German: Alpenrhein, pronounced [ˈalpn̩ˌʁaɪn] ) is the section of the river Rhine from its source in the Swiss Alps to Lake Constance. It begins in the centre of the Swiss canton of Grisons (Kanton Graubünden), and later forms the border between Switzerland to the west and Liechtenstein to the east, and later between Switzerland and Austria. It flows through the Alpine Rhine Valley.

There is no shipping on the Alpine Rhine.

The Alpine Rhine is formed near Tamins-Reichenau by the confluence of the rivers Anterior Rhine (Vorderrhein) and the Posterior Rhine (Hinterrhein). Its mouth is at the Upper Lake Constance.