Calasca-Castiglione is a comune (municipality) in the Province of Verbano-Cusio-Ossola in the Italian region Piedmont, located about 120 kilometres (75 mi) northeast of Turin and about 35 kilometres (22 mi) northwest of Verbania.

Calasca-Castiglione borders the following municipalities: Antrona Schieranco, Bannio Anzino, Borgomezzavalle, Pallanzeno, Piedimulera, Pieve Vergonte, Rimella, Valstrona, Vanzone con San Carlo.