Mesero (Italian: [ˈmeːzero]; Milanese: Mesar [ˈmeːzar]) is a comune (municipality) in the Metropolitan City of Milan in the Italian region Lombardy, located about 25 kilometres (16 mi) west of Milan.

Mesero borders the following municipalities: Inveruno, Cuggiono, Ossona, Marcallo con Casone, Bernate Ticino.